High-Throughput Validation of Synthetic Binders

Standardizing SPR and BLI protocols for the rapid assessment of library-generated protein variants at scale.

August 11, 2026

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The Validation Bottleneck
Surface Plasmon Resonance (SPR)
Bio-Layer Interferometry (BLI)
Standardized Analysis Pipeline
Data Quality Metrics

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Overlapping kinetic binding curves drawn as fine lines on an ivory background, with one primary curve highlighted in coral.

Assay Development

14 min

Quantifying Binding Kinetics in Complex Serum

Navigating the challenges of off-target interactions and non-specific binding in physiological environments.

Ribbon diagram of staphylococcal enterotoxin B2 with surface residues colored by binding propensity, highlighting a dominant aromatic patch near residues 90-94.

Computational Protein Engineering

Put these methods to work on your target.

Send us a target surface and we will scope a feasibility review, design binders, and report the same objective metrics our research is built on.

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14 min

Staphylococcal Enterotoxin B2: A Surface-First Binder Design Campaign

A surface-fingerprinting and parallel binder generation campaign against staphylococcal enterotoxin B2 produced 28 developability-scored candidates, with bindcraft designs dominating the top ranks by generator confidence.

Blueprint-style illustration of a protein scaffold with alpha helices and beta sheets drawn on a cream journal page.

Protein Binders

22 min

Scaffold Engineering for Multispecific Binding

Methods for introducing multiple paratopes onto a single rigid framework without compromising core stability.

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High-Throughput Validation of Synthetic Binders

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Quantifying Binding Kinetics in Complex Serum

Put these methods to work on your target.

Staphylococcal Enterotoxin B2: A Surface-First Binder Design Campaign

Scaffold Engineering for Multispecific Binding